It’s easy to move this activity center from room to room as your baby jets off on his Journey of Discovery. Its bouncy seat rotates 360 degrees, while supporting baby with a comfy, machine washable seat pad and high seat back. Your baby will love exploring every tactile sensation of the multi-sensory postcards – a soft souvenir from his adventure “travel.” This Baby Einstein standing jumper is made for growing babies, so the four height positions are easy to adjust. See more of the world with every spin of the multi-color globe, which plays internationally-inspired music and introduces instrument sounds and phrases in three languages. Play with the North Pole’s friendly snowman and ice cube bead chaser, or discover the deep seas with Baby Neptune and his submarine. Each of the 12 activities takes your baby on a global expedition. Put the whole world in perspective with this activity jumper. ![]() Adjusts to 4 height positions for growing babies.Spinning globe plays internationally-inspired music and instrument names.Packaging note: Ships in the manufacturers original packaging, which may reveal the contents. Adventure and travel-themed activities captivate baby Little Einstein Bouncer (4.0) 4 stars out of 11 reviews 11 reviews.Seat rotates 360 degrees for baby to explore.Explore the world right from your living room.Baby Einstein Neptunes Ocean Discovery By Baby Einstein USD 125.90. Make out which little einsteins bouncer is best. ![]() Features and benefits of Journey of Discovery Jumper™ – 10917 We researched 11 greatest little einsteins bouncer deals over the previous 3 years.
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Wish there were a ‘music off’ option as the slow piano/violin music is annoying when the only other sounds are naturalistic ones which are quite well done. I can’t honestly give this one star because the graphics are superb and the atmosphere would be great if there were anything going on within it. If you need any help please contact us at le BaronĪfter spending quite a while slowly trudging around a rocky landscape in the form of an avatar who can’t seem to step over any stone that’s over 10cm tall, I started to get bored. We strongly recommend playing the game with sound on, it's great with headphones. PC Gamer said it “provokes thought and feeling in a way few other games do.” It also won praise for its visuals and music, with The Daily Telegraph saying “Dear Esther's visuals are majestic”, and Jessica Curry’s soundtrack receiving awards and nominations from BAFTA among others.”ĭear Esther includes subtitles in French, German, Spanish and Russian. Since the original release, Dear Esther has sold over one million units and is seen as a benchmark in interactive and emotional storytelling. Generally recognised as kick-starting the walking simulator subgenre, Dear Esther features dynamic narration that means the story changes each time you return to the island. We’re invited to explore the windswept island, descending into an eerie, otherworldly story where reality fragments and falls apart. As he takes his first step forward, he starts to speak: “Dear Esther.” and so begins a dreamlike, complex tale of love, loss and redemption. The Chinese Room’s cult classic Dear Esther arrives on iOS for the first time, in this faithful interpretation of the internationally renowned game.Ī man stands on a desolate Hebridean shore. ![]() With Navicat Cloud, you can leverage every minute of your day to maximize your productivity. ![]() Synchronize your connection settings, models, queries and virtual groups to our Navicat Cloud service so you can get real-time access to them, and share them with your coworkers anytime and anywhere. No matter where you are, you can always get the job done. Set an automation for repeatable deployment process like database backup and script execution at a specific time or day. Our powerful local backup/restore solution and intuitive GUI for Oracle Data Pump/SQL Server Backup Utility guides you through the backup process and reduces the potential for errors. 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GSPT1 is a protein involved in the termination of translation, a process in which ribosomes synthesize proteins after the transcription of DNA to RNA. (WSE:CTX), a biopharmaceutical company focused on the development of targeted protein degradation (TPD) drugs for cancer and autoimmune diseases, today announces the molecular targets of one of its core pipeline projects designated CT-01, which is focused on the development of TPD therapy for hepatocellular carcinoma (HCC).Ĭompelling in-vitro and in-vivo preclinical data demonstrate that CT-01 candidate compounds induce degradation of Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1), Sal-like protein 4 (SALL4) and another undisclosed neo-substrate with essential function in tumorigenesis. WROCLAW, Poland, Ap(GLOBE NEWSWIRE) - Captor Therapeutics S.A. CT-01 on track to enter clinical development in 2023.Compelling pre-clinical data generated demonstrating HCC tumor regression.The unique degradation profile supports the strong competitive potential of the program.CT-01 compounds induce degradation of GSPT1, SALL4 and another as yet undisclosed neo-substrate.“ However, we are still learning how to use this scientific potential to generate commercial value. “ The number of biotech companies in Poland is growing, as well as the level of investment in science, ” Sagan said. Other notable Polish biotechs include Warsaw-based OncoArendi and Selvita from Krakow. “ We believe that the way to a successful degrader may depend on the target ,” Sagan said.Ĭaptor Therapeutics is part of the expanding biotech scene in Poland, which includes Pure Biologics, based in the same city as Captor. Rather than investing in one type of degrader drugs like many other companies do, Captor Therapeutics is exploring different classes of degrader drugs. “ We can expect that several degraders will enter clinical trials in the near future ,” Sagan said to me. Other companies are springing up to develop similar drugs, such as the UK biotech Polyprox, which makes PROTACS out of proteins, rather than small molecules. The most advanced PROTACs belong to the US biotech Arvinas, and are currently in phase I. Many companies focus on the development of PROTACS, which are chimeric small molecules designed to trigger the destruction of target proteins. The protein degradation approach is hot at the moment, especially in oncology. This could then allow new classes of drugs to enter the market for difficult-to-treat conditions such as cancer and autoimmune diseases. Protein degradation has the potential to open up the undruggable proteome. The company has raised €33M so far in grants and investments to fuel the development of its cancer treatments. “ In this case, taking the protein down provides a clear advantage over simple inhibition ,” Maria Sagan, biotechnology specialist at Captor Therapeutics, told me.įounded in 2017, Captor Therapeutics is currently in the early preclinical stages, and hasn’t yet disclosed which particular diseases it will be targeting. In contrast, Captor can get access to proteins inside the cell that have more specific roles, an approach that is therefore less likely to result in side effects.Īnother advantage is that proteins can interact with other proteins to contribute to a disease, even if they are being blocked from their main function. For one, many existing drugs cause side effects because they target cell surface proteins that have many other roles besides the one that is causing the disease. This approach has a number of advantages over traditional drugs. This is done by labeling the proteins with a special tag that sends the protein to the ‘trash can’ of the cell, called the proteasome. Instead of designing drugs that either activate or block the target they bind to, the company instructs the cell to degrade the target. This can be a problem, since many of these proteins could be viable targets for treating diseases, such as some transcription factor proteins in cancer.Ĭaptor Therapeutics is developing small molecule drugs capable of targeting these undruggable proteins. The rest of the proteins can’t bind to existing small molecule drugs, making them ‘undruggable’. Small molecule drugs are able to target a small minority of proteins in the cell, such as cell surface proteins. Mission : To develop cancer treatments able to degrade proteins that are normally outside the reach of traditional drugs, called the ‘undruggable proteome’. In the Polish city of Wrocław, Captor Therapeutics is developing cancer treatments that destroy disease-causing proteins. ![]() Why can’t I get my pre-departure drink?” Subsequently, as standard protocol, T.C. saying, “Well, that’s why I like you guys. When he was asking BURK for his meal order, the elderly seemed fine but then got “snippy” with T.C. stated this interaction occurred when he was taking the first-class passengers’ meal orders before takeoff," added the affidavit. because he did not receive his red wine before departure. Generally, first-class passengers receive drinks from the flight attendant before takeoff.Īccording to the victim, he ran out of time and was not able to give BURK his pre-ordered alcoholic beverage, which was red wine. Delta flight crew members on Delta flight 517 were reporting interference with a flight attendant, T.C., by a passenger, BURK, who had made sexual advances toward T.C," read the affidavit.įurther, it said that the flight attendant and victim, T.C., was working in the first-class passenger area, where BURK was sitting in seat 5A. (AKDT), FBI Operations Center in the Anchorage Field Office received a phone call from Anchorage Airport Police Dispatch, who reported an incident which was called in from Delta Airlines. Supporting medical or religious documentation will be required where applicable.According to an affidavit, the unruly passenger was identified as 61-year-old David Alan BURK, who was travelling from Minnesota to Alaska on a Delta Airlines flight on April 10, and had made sexual advances toward TC (Crew member). ![]() is an Equal Employment Opportunity / Affirmative Action employer and provides reasonable accommodation in its application and selection process for qualified individuals, including accommodations related to compliance with conditional job offer requirements. View the 2023 Hiring Process Guide for an overview of the flight attendant role, application steps and answers to some frequently asked questions.ĭelta Air Lines, Inc. ![]() The top priority for every Delta flight attendant is to ensure the safety and comfort of all customers while providing exceptional service. With a global network spanning over 300 destinations, Delta is also seeking bilingual (also known as language of destination) applicants who have fluency in English and one of the following languages: Czech, Danish, Dutch, French, Greek, German, Hebrew, Italian, Japanese, Korean and Swedish. WHAT’S REQUIRED TO BE A DELTA FLIGHT ATTENDANT?Īpplicants must have a high school diploma, GED or high school equivalency, the ability to work in the U.S., speak, read and write English fluently and be at least 21 years of age at the time of application submission.ĭelta flights operate daily, overnight year-round therefore, flight attendants must be flexible and willing to fly both international and domestic routes. Note that candidates who previously applied but were not selected to advance must wait three months from the time of receiving a previous disqualification email and for a new job number to be posted to reapply. Interested candidates can apply starting today. If you have a passion for people, adventure and creating memories, this is the opportunity for you. “We’re excited to keep the momentum going and welcome more trainees for classes through the end of the year.” “This is a historic year for flight attendant hiring, as we plan to grow our team by more than 4,000,” said Jennifer Martin, Managing Director – IFS CX, Learning and Hiring. Delta is hiring more flight attendants for 2023, adding to the 1,940 new faces that have come on board since February. ![]() Skitch is currently free, Screeny is $15 and ScreenFlow $99 - all are available on the Mac App Store. Included are the basics such as the Editor, Tools, and Effects. Snagit makes it easy to create eye-catching images and videos for quick. This iBook will teach you all the fundamentals of Snagit for Mac and help you get jump started on using this awesome software. 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